I recently found out about a very useful AIR application called "Moderator" created by Danny Dura, Platform Evangelist at Adobe. What the application does is give you access to your comment moderation queue if you're running a WordPress blog.
Installation is very easy, you first install a WordPress plugin and activate it, then download and install the Moderator AIR application. You'll be prompted to log in with your blog administrator credentials and endpoint, usually that is the xmlrpc.php file inside your blog installation directory.
You can specify in the settings how often the application should check the moderation queue and when comments show up you can simply choose to accept, mark as spam or delete.
I'm really pleased with the app, saves me from constantly having my blog admin open in a tab of my browser and manually hitting refresh all the time.
From what I've heard Danny is going to add Growl notification support in an upcoming update which would be a great enhancement. Two thumbs up!
More information and download here: http://www.danieldura.com/code/moderator